Avana 50

Avanafil, marketed under the brand name Stendra, is a medication approved by the U.S. Food and Drug Administration (FDA) in April 2012 for the treatment of erectile dysfunction (ED) in men.

As a phosphodiesterase type 5 (PDE5) inhibitor, avanafil works by increasing blood flow to the penis, facilitating the achievement and maintenance of an erection during sexual activity.

Mechanism of Action

Avanafil selectively inhibits the PDE5 enzyme, which is responsible for the breakdown of cyclic guanosine monophosphate (cGMP) in the corpus cavernosum of the penis. By preventing this breakdown, avanafil enhances the effects of nitric oxide, leading to the relaxation of smooth muscle and increased blood flow, resulting in an erection.

Dosage and Administration

Avanafil is available in tablet strengths of 50 mg, 100 mg, and 200 mg. The recommended starting dose is 100 mg, taken approximately 15 to 30 minutes before anticipated sexual activity. The maximum recommended dosing frequency is once per day. Dosage adjustments may be necessary based on individual response and tolerability.

Efficacy

Clinical studies have demonstrated that avanafil is effective in treating ED in various populations, including men with diabetes mellitus. In a 12-week, multicenter, double-blind, placebo-controlled study, both 100 mg and 200 mg doses of avanafil significantly improved erectile function compared to placebo. Notably, avanafil was effective as early as 15 minutes after dosing and maintained efficacy for more than six hours.

Safety and Side Effects

Avanafil is generally well-tolerated. Common side effects include headache, nasopharyngitis, flushing, and sinus congestion. These adverse events are typically mild and transient. As with other PDE5 inhibitors, avanafil should not be used concomitantly with nitrates or nitric oxide donors due to the risk of significant hypotension. Patients with cardiovascular conditions should consult their healthcare provider before initiating treatment with avanafil.

Conclusion

Avanafil offers a rapid-onset and effective option for men seeking treatment for erectile dysfunction. Its quick action and favorable side effect profile make it a valuable addition to the array of PDE5 inhibitors available for ED management. As with all medications, it is essential for patients to consult with their healthcare provider to determine the most appropriate treatment plan based on individual health status and needs.